What Are The Benefits SAM-e Supplement?



SAME-e, The Key MOOD Elevator

In order to understand the benefits SAM-e supplement provides, it’s importance among the all-natural mood elevators and to discover the best brand SAM-e supplement one must first understand what is SAM-e whether one is living The Best Ketogenic lifestyle for Beginners or otherwise.

SAM-e is a chemical component that occurs naturally and it is present in all cells of the body.

It is essential in more than 200 metabolic pathways.



SAM-e is found naturally in one’s body.

SAM-e is s-adenosylmethionine which is a compound that comes from

  • Methionine which is an essential amino acid, and
  • adenosine triphosphate, which is an energy-producing compound

SAM-e is available in the US as a supplement and in Europe as a prescription drug.

  SAM-e can be taken three ways, which are:

  • Oral
  • Intravenously, or
  • As an injection.



SAM-e was first discovered by Giulio Cantoni in 1952.

In bacteria, SAM-e is bound by the SAMriboswitch, which regulates genes involved in methionine or cysteine biosynthesis

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAM-e.



A recent study conducted at Harvard Medical School and Massachusetts General Hospital confirmed and cited the benefits of SAM-e for mood elevation

MOOD Elevation With SAM-e

SAM-e is involved in methylation which supports a number of biochemical reactions in one’s blood.

The Journal of Psychiatry & Neuroscience published a review recently mentioned over 35 methylation reactions that involve SAM-e.

Some of the important biochemical reactions in which SAM-e is involved are:

  • Mood Elevating properties
  • DNA repair
  • Gene expression
  • Helping the cell’s membrane maintain fluidity
  • Improving neurotransmitters
  • Synthesizing proteins
  • Metabolizing fats
  • Metabolizing minerals
  • Playing a role in the formation, activation and breakdown of many chemicals, including hormones and proteins.
  • SAM-e increases the turnover of serotonin and may increase levels of dopamine and norepinephrine.
  • Anti-inflammatory properties
  • Analgesic effects
  • Pain relief
  •  Improving physical function
  •  Relieving depression
  •  Combating liver disease
  •  Combating osteoarthritis
  •  Combating fibromyalgia



SAM-e should not be used with pharmaceutical antidepressants.

The side effects of SAM-e are rare and usually very mild if at all.

Some of the rare side effects can be:

  • Anxiety
  • Sweating
  • Constipation
  • Diarrhea
  • Upset stomach
  • Nausea
  • Mild insomnia
  • Dizziness
  • Irritability

Further, if one has a bipolar disorder then one should talk to one’s Dr before supplementing with SAM-e.

And, if one has a compromised immune system caused by an infection one should avoid SAM-e because SAM-e can increase the growth of such pathogen.

   Some possible interactions are with:

  • Amphetamines
  • Narcotics 
  • Antidepressants
  • Antipsychotics
  • Dextromethorphan
  • ST. John’w wort

Taking SAM-e with the above noted medications could cause large amounts of serotonin to accumulate in one’s body



Fortunately one can obtain enteric coated SAM-e for supplementation from LifeExtension, which is coated so as not to cause any stomach upset.

In addition to mood elevation, SAM-e promotes brain and liver health.

Mood Enhancement With SAMe, ADD TO CART as on SUPER SALE

Yes, I want SAM-e for my mood enhancement and well being!, then one should ADD TO CART and GET the  SAM-e S-Adenosyl-Methionine 200 mg, 30 enteric coated tablets on SUPER SALE.

Following is LifeExtension’s Detailed Explanation On The Excellent SAMe Which It Provides:  

SAMe helps maintain stable mood and joint function without side effects.

In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health.

Largely known for its effects on optimal mood, SAMe has also shown benefits for the liver, brain, and joints.

 Benefits at a glance:

  • Helps maintain a stable mood
  • Helps maintain liver health
  • Helps maintain healthy joint function

Life Extension® first introduced SAMe (S-Adenosyl-Methionine) in 1997, and researchers continue to discover impressive benefits of this versatile nutrient.

SAMe is an amino acid derivative normally synthesized in the body that may become depleted with sickness or age.

Supplementing with SAMe plus folate, trimethylglycine (TMG or betaine), vitamins B6 and B12 appears to be an effective way to overcome this deficiency.

SAMe is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, and catecholamines and other neurotransmitters.

SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin.

SAMe facilitates glutathione4,5usage, which improves the body’s antioxidant defense.

It also helps maintain acetylcholine levels, which are necessary for cognitive function.

SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe.

Its findings show the efficacy of SAMe in helping to maintain a stable mood and joint function without any side effects.

Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.

SAMe has multi-modal mechanisms of action that are used throughout the body and especially in the liver.

In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions.

SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant.

When liver function is compromised, glutathione is depleted, which leads to free radical damage.

In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

A recent study conducted at Harvard Medical School and Massachusetts General Hospital cited the benefits of SAMe for mood elevation.

In addition, a report published in Germany indicates that SAMe may help maintain healthy neurological function. The report revealed that:

  • SAMe increased glutathione levels by 50% and glutathione enzyme activity by 115%.
  • SAMe decreased measurement of free radical activity by 46%.
  • SAMe inhibited lipid peroxidation by 55% in culture.

SAMe’s ability to boost brain cell methylation facilitates youthful DNA enzymatic actions which may help account for SAMe’s mood-elevating properties.

These enzymatic reactions are required for the healthy conversion of neurotransmitters such as serotonin and dopamine.



In order to understand the benefits SAM-e supplement provides, its importance among the all-natural mood elevators and to discover the best brand SAM-e supplement one must first understand about SAME-e has been explained.

This understanding of SAM-e is important whether one is living The Ketogenic lifestyle For Healthy Longevity or otherwise.


This is not Medical Advice. Nothing herein this article should be considered or used as any personal medical advice, and one should always consult with one’s personal Doctor before making any changes in one’s diet, routine or following any information given, suggested or provided herein. No statements herein have been approved by the FDA.


Please advise below any comments and/or questions you have regarding this post.
Also, what additional topics or subjects would you like to have covered in a future post?
Thank you,
Ted, Founder of this Keto-Longevity.com site
e-Mail: Keto.Longevity@gmail.com
Twitter: Ted at Twitter



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